Our Current Studies

Rheumatology Focused Studies

INDIGO

A clinical trial to evaluate the efficacy of and safety of Obexelimab in patients with IgG4-Related Diseases.

PI: Dr. Zachary Wallace

CRC Contact: Zach Williams
email: zkwiliams@mgh.harvard.edu

RheumSCAN

An observational study to understand how COVID-19 infection affects the lungs in people with rheumatoid arthritis.

PI: Dr. Zachary Wallace

CRC Contact: Madi Negron
email: mnegron3@mgh.harvard.edu

LONG-TOX

A study looking at the long-term effects of glucocorticoid toxicity in patients with rheumatic diseases.

PI: Dr. Naomi Patel

CRC Contact: Isha Jha & Grace McMahon
email: ijha@mgh.harvard.edu & gamcmahon@mgh.harvard.edu

TRUST Trial

A clinical trial to examine two methods of treating gout (targeting serum urate levels vs treating to avoid symptoms).

PI’s: Drs. Hyon Choi & Michael Barry

CRC Contact: Kiara Tan
email: ktan9@mgh.harvard.edu
Website: trust-gout.mgh.harvard.edu

PR3-Resilient Remission (PRRR)

A clinical trial to examine the effects of Obinutuzumab vs Rituximab in PR3-Patients with AAV

PI: Dr. Zachary Wallace

CRC Contact: Cole Johnson
email: aavresearch@mgh.harvard.edu

ANCA-Associated Vasculitis (AAV) Registry

A prospective registry of patients with AAV to identify phenotypes and genome analysis as well as determine efficiency and complications of treatment.

PI: Dr. Zachary Wallace

CRC Contact: Cole Johnson
email: aavresearch@mgh.harvard.edu

SAVe

A study examining subclinical atherosclerosis in patients with ANCA-Associated Vasculitis.

PI: Dr. Zachary Wallace

CRC Contact: Zach Williams
email: aavresearch@mgh.harvard.edu

RheumCARD

A study looking at COVID-19 and Rheumatic Diseases

PI: Dr. Zachary Wallace

CRC Contact: Shruthi Srivatsan
email: ssrivatsan1@mgh.harvard.edu

SLE – PBMC Collection

A study collecting and analyzing PBMCs from autoimmune patients.

PI’s: Drs. Jacquelyn Nestor, April Jorge, & Andrew Luster

CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu

ALE10

A drug trial examining distinct immunophenotypes to validate and enhance rational treatment with Mycophenolate Mofetil alone or with Voclosporin for SLE patients.

PI: Dr. April Jorge

CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu

POETYK

A drug trial to evaluate the efficacy and safety of Deucravacitinib in patients with active SLE.

PI: Dr. April Jorge

CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu

CORODECT

An observational imaging study examining the presence of coronary monosodium urate crystals using dual-energy CT technology

PI: Dr. Chio Yokose

CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org

Gout and Crystal Arthropathy Center (GCAC)

A team at MGH dedicated to delivering personalized and comprehensive care for those with gout, psuedogout, and other crystal arthropathies both through treatment and research

PI: Hyon Choi

CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org
website: goutcenter.mgh.harvard.edu

SAVE-Care Consortium

A consortium of eight different locations, including MGH, working to investigate the potential usage of SGLT2i, a class of type-2 diabetes medication, for gout treatment

PI: Hyon Choi

CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org
website: save-care.mgh.harvard.edu

Allergy Focused Studies

DACAT

A clinical trial and mechanistic study to optimize the approach to cephalosporin allergy and advance future diagnostics.

PI: Dr. Kimberly Blumenthal

CRC Contact: Dylan Norton
email: dtnorton@mgh.harvard.edu
website: antibioticallergy.massgeneral.org
ClinicalTrials.gov

Immune Mechanisms in Allergic and Immunologic Disease

Registry to track antibody response to SARS CoV-2 Vaccine in patients with immunodeficiency and allergic disease.

PI: Dr. Sara Barmettler

CRC Contact: Joseph Hong
email: jhong20@mgh.harvard.edu

US Drug Allergy Registry

Databank and biobank of patients who are seen for drug allergy at Massachusetts General Hospital and participating sites. 

PI: Dr. Kimberly Blumenthal

CRC Contact: Maddy Eippert
email: meippert@mgh.harvard.edu
website: usdar.massgeneral.org

COVID-19 Vaccine Allergy Registry

National patient and clinician registries for patients who had allergic and cutaneous reactions after COVID-19 vaccination. 

PI: Dr. Kimberly Blumenthal

CRC Contact: Liam Smith
email: lsmith99@mgh.harvard.edu
website: allergyresearch.massgeneral.org

Economic Analysis of Eosinophilic Esophagitis

Time-Driven Activity-Based Costing of Unsedated Transnasal Esophagogastroduodenoscopy vs. Sedated Upper Endoscopy

PI: Dr. Kimberly Blumenthal

CRC Contact: Liam Smith
email: lsmith99@mgh.harvard.edu

Advancing Equitable Penicillin Allergy De-Labeling (PEN-EQ)

Improving equitable access to penicillin allergy de-labeling in the Boston area by employing quantitative, qualitative and implementation science research methods

PI: Dr. Kimberly Blumenthal

CRC Contact: Maddy Eippert
email: meippert@mgh.harvard.edu

Please reach out to CRC contacts if you would like more information about our current research. We are happy to provide as much information as possible. We are excited about our future and the future of rheumatology and allergy research.