Rheumatology Focused Studies
INDIGO
A clinical trial to evaluate the efficacy of and safety of Obexelimab in patients with IgG4-Related Diseases.
PI: Dr. Zachary Wallace
CRC Contact: Zach Williams
email: zkwiliams@mgh.harvard.edu
RheumSCAN
An observational study to understand how COVID-19 infection affects the lungs in people with rheumatoid arthritis.
PI: Dr. Zachary Wallace
CRC Contact: Caleb Bolden
email: cbolden@mgh.harvard.edu
LONG-TOX
A study looking at the long-term effects of glucocorticoid toxicity in patients with rheumatic diseases.
PI: Dr. Naomi Patel
CRC Contact: Isha Jha & Grace McMahon
email: ijha@mgh.harvard.edu & gamcmahon@mgh.harvard.edu
TRUST Trial
A clinical trial to examine two methods of treating gout (targeting serum urate levels vs treating to avoid symptoms).
PI’s: Drs. Hyon Choi & Michael Barry
CRC Contact: Kiara Tan
email: ktan9@mgh.harvard.edu
Website: trust-gout.mgh.harvard.edu
PR3-Resilient Remission (PRRR)
A clinical trial to examine the effects of Obinutuzumab vs Rituximab in PR3-Patients with AAV
PI: Dr. Zachary Wallace
CRC Contact: Cole Johnson
email: aavresearch@mgh.harvard.edu
ANCA-Associated Vasculitis (AAV) Registry
A prospective registry of patients with AAV to identify phenotypes and genome analysis as well as determine efficiency and complications of treatment.
PI: Dr. Zachary Wallace
CRC Contact: Cole Johnson
email: aavresearch@mgh.harvard.edu
SAVe
A study examining subclinical atherosclerosis in patients with ANCA-Associated Vasculitis.
PI: Dr. Zachary Wallace
CRC Contact: Zach Williams
email: aavresearch@mgh.harvard.edu
RheumCARD
A study looking at COVID-19 and Rheumatic Diseases
PI: Dr. Zachary Wallace
CRC Contact: Shruthi Srivatsan
email: ssrivatsan1@mgh.harvard.edu
SLE – PBMC Collection
A study collecting and analyzing PBMCs from autoimmune patients.
PI’s: Drs. Jacquelyn Nestor, April Jorge, & Andrew Luster
CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu
ALE10
A drug trial examining distinct immunophenotypes to validate and enhance rational treatment with Mycophenolate Mofetil alone or with Voclosporin for SLE patients.
PI: Dr. April Jorge
CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu
POETYK
A drug trial to evaluate the efficacy and safety of Deucravacitinib in patients with active SLE.
PI: Dr. April Jorge
CRC Contact: Kila Panchot
email: kpanchot@mgh.harvard.edu
CORODECT
An observational imaging study examining the presence of coronary monosodium urate crystals using dual-energy CT technology
PI: Dr. Chio Yokose
CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org
Gout and Crystal Arthropathy Center (GCAC)
A team at MGH dedicated to delivering personalized and comprehensive care for those with gout, psuedogout, and other crystal arthropathies both through treatment and research
PI: Hyon Choi
CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org
website: goutcenter.mgh.harvard.edu
SAVE-Care Consortium
A consortium of eight different locations, including MGH, working to investigate the potential usage of SGLT2i, a class of type-2 diabetes medication, for gout treatment
PI: Hyon Choi
CRC Contact: Saiajay Chigurupati
email: schigurupati@mgb.org
website: save-care.mgh.harvard.edu
Allergy Focused Studies
Immune Mechanisms in Allergic and Immunologic Disease
Registry to track antibody response to SARS CoV-2 Vaccine in patients with immunodeficiency and allergic disease.
PI: Dr. Sara Barmettler
CRC Contact: Joseph Hong
email: jhong20@mgh.harvard.edu
US Drug Allergy Registry
Databank and biobank of patients who are seen for drug allergy at Massachusetts General Hospital and participating sites.
PI: Dr. Kimberly Blumenthal
CRC Contact: Emily Byrne
email: ecbyrne@mgh.harvard.edu
website: usdar.massgeneral.org
COVID-19 Vaccine Allergy Registry
National patient and clinician registries for patients who had allergic and cutaneous reactions after COVID-19 vaccination.
PI: Dr. Kimberly Blumenthal
CRC Contact: Liam Smith
email: lsmith99@mgh.harvard.edu
website: allergyresearch.massgeneral.org
Economic Analysis of Eosinophilic Esophagitis
Time-Driven Activity-Based Costing of Unsedated Transnasal Esophagogastroduodenoscopy vs. Sedated Upper Endoscopy
PI: Dr. Kimberly Blumenthal
CRC Contact: Liam Smith
email: lsmith99@mgh.harvard.edu
Advancing Equitable Penicillin Allergy De-Labeling (PEN-EQ)
Improving equitable access to penicillin allergy de-labeling in the Boston area by employing quantitative, qualitative and implementation science research methods
PI: Dr. Kimberly Blumenthal
CRC Contact: Emily Byrne
email: ecbyrne@mgh.harvard.edu
Please reach out to CRC contacts if you would like more information about our current research. We are happy to provide as much information as possible. We are excited about our future and the future of rheumatology and allergy research.
